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KMID : 0387720150260010054
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Korean Journal of Blood Transfusion
2015 Volume.26 No. 1 p.54 ~ p.59
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Unexpected Antibody Screening Tests Including Dia in Patients with a History of Multiple Packed Red Cell Transfusion
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김문진:Kim Moon-Jin
김경희:Kim Kyung-Hee/박필환:Park Pil-Hwan/서일혜:Seo Yiel-Hea/안정열:Ahn Jeong-Yeal/서자영:Seo Ja-Young/정지훈:Jeong Ji-Hun/이환태:Lee Hwan-Tae
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Abstract
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Background: The Dia antigen has been detected with a relatively higher incidence among Koreans with a frequency of 6.4 to 14.5%. In South Korea, commonly used unexpected antibody screening panels do not include Dia antigen positive cells. We screened patients who previously received multiple packed red cell transfusion using two cells without Dia antigen and three cells including Dia antigen to evaluate the effectiveness of three screening cells.
Methods: A total of 307 patients who had received packed red cell transfusion more than three times during the last 6 months in our hospital were enrolled. They were employed for unexpected antibody screening test using two sets of screening cells not including Dia antigen and three sets including Dia antigen by LISS/Coombs gel card.
Results: Among 307 patients, 12 were positive using two cells and 15 were positive using three cells. Three patients showed discordant result and one of them was positive for the cell including Dia antigen (0.33%). Antibody identification was performed using the panel which does not include Dia antigen and it was negative for all of the antigens listed on the panel so that the presence of anti-Dia was suspected.
Conclusion: It can be difficult to use three cells including Dia antigen for all patients due to cost, however, use of three cells is recommended in patients with multiple transfusion history. (Korean J Blood Transfus 2015;26:54-59)
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KEYWORD
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Dia, Antibody screening, Transfusion, Cross-matching
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